David G. Nathan, M. A revolution in cancer drug therapy has been brewing for the past twenty years. The three decades of clinical research carried out between and were largely devoted to the discovery and clinical trials of combinations of DNA-damaging agents that might best be described as carpet-bombing therapeutics. Great strides were made with these agents in certain diseases such as the hematological malignancies particularly childhood leukemia , Hodgkin’s lymphoma, and the malignancies of the head and neck, colorectum, ovaries and testes and, to a certain extent, breast cancer. But the major epithelial cancers, including lung, colon and prostate, remain largely recalcitrant. A new paradigm is sorely needed. Hope that a better concept of cancer therapy might emerge began to be appreciated in the s and s. Evidence gathered by several laboratories demonstrated the correctness of the century-old postulate of Theodor Boveri that cancer is due to chromosome injury 1.
Firebombing of Tokyo
The program, which is available to any of the 7, RIAs custodying at TD, starts with an anonymous online profile that should take between 10 minutes to a half hour to complete, depending on how much detail is provided. But without the online profiles and algorithms, it was a slower and more labor-intensive process. But, while the new program gets high marks for effort and automation, it is also seen as limiting because it only connects RIAs with those potential buyers and sellers that custody at TD.
Whenever I speak with local companies the main problem is always, n ot enough new customers. This is especially true for restaurants or service-based businesses. Finding new customers in their local market is a constant struggle. Their efforts usually leads to using high priced TV and radio spots, or coupon services like Groupon and Valpak in the hopes of landing a new customer. Many companies use strategies like print ads, or paid services like Home Advisor.
All these strategies work somewhat, but most are frustrated and simply breaking even on their marketing strategies. So, I began researching what these local companies all had in common with their marketing practices. Very few had an intentional strategy focused on digital marketing for the local market. Plus, Facebook owns Instagram and all Instagram ads run through the Facebook platform anyway. The prospect of digital marketing is stressful and overwhelming- mainly because of a lack of understanding about digital marketing is the primary obstacle for local businesses.
On the whole, this would be considered a success. However, what if you could achieve 6X ROI and still pick up new customers?
US Carpet-Bombs ‘ISIS-Infested’ Island
Susie Lee, right, with the help of Katrina Hess, has developed a new online dating app called Siren. The women pose for a portrait in Hess’ studio space, which has an exposed tub. Wexler, a Portland writer who edited the book “Awful First Dates: Hysterical, True, and Heartbreakingly Bad,” has been the recipient of crude, overtly sexual opening lines.
It didn’t. But that doesn’t stop thousands of men from inundating women with messages in dating apps — today’s virtual version of a singles bar — that are by turns gross, hilarious, objectifying and just plain sad. She has also received “the carpet bomb” — the impersonal, copied-and-pasted form letter sent to hundreds of women at a time; the cheesy pickup line; and numerous illiterate greetings like, “Sup, gorgus.
The first German bombing of London on the night of Aug 24, , Privacy and cookiesJobsDatingOffersShopPuzzlesInvestor SubscribeRegisterLog in the first carpet bombing attack was directed on to the city of Lubeck.
British Broadcasting Corporation Home. Is there any such thing as a moral bombing strategy? Detlef Siebert examines the impossible choices of war. The destruction of Dresden remains a serious query against the conduct of Allied bombing. More than half a century later, the strategic bombing campaign continues to nag the national conscience. Some historians go as far as to suggest that by bombing cities the British ‘descended to the enemy’s level’ John Keegan.
This is, of course, an exaggeration. The bombing of Dresden cannot be equalled with the horrors of Auschwitz.
What to Know About ‘Love Bombing,’ the Trend That’s Ruining Dating for Everyone
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It’s travelling from Musée Bargoin, Clermont-Ferrand, France. Date: January 10, ; Next: Critical Mass.
It was followed by a ground operation by Iraqi forces. Large bombing raids such as the one shown in the video have become a relatively rare occurrence since the Isis caliphate was defeated earlier this year, but the terror organisation is already regrouping in parts of Iraq. Much as it did in the prelude to its meteoric rise in , Isis has been carrying out targeted assassinations of local political, tribal, and security leaders — and indeed anyone who it deems to be cooperating with the Iraqi government.
The US-led mission to defeat Isis is continuing to work with Iraqi forces to go after the resurgent Isis pockets. You can find our Community Guidelines in full here. Want to discuss real-world problems, be involved in the most engaging discussions and hear from the journalists? Start your Independent Premium subscription today. Independent Premium Comments can be posted by members of our membership scheme, Independent Premium. It allows our most engaged readers to debate the big issues, share their own experiences, discuss real-world solutions, and more.
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No, we can’t just ‘bomb the hell out of ISIS,’ Donald Trump
The first German bombing of London on the night of Aug 24, , was an accident but sparked a war of attrition that would last for five years. German aircraft heading for a military target flew off course and mistakenly dropped their bombs on central London. The raid was interpreted by Winston Churchill as deliberate and the following night 40 British bombers were sent on their first attack to the German capital Berlin.
Does a carpet bombing message strategy work in online dating? In this article I discuss the tactic in detail and let you know. Should you, or.
The coalition said F15 and F35 warplanes took part in the bombing on Qanus Island in the central province of Salaheddine, north of Baghdad, the AP reports. ISIS sleeper cells have since carried out deadly bombings in Iraq. A video released by the military showed massive explosions creating mushroom clouds billowing from the island that appeared to have been subjected to carpet bombing.
The coalition said Iraqi special forces carried out ground clearance operations after the bombing, Stars and Stripes reports. Read more Iraq stories. New features on our site. Breaking News. By Newser Editors and Wire Services. Bombs explode on Qanus Island. Special Joint Operations Task Force. Email This Story. Message up to characters.
Soviet-made bomb found near kindergarten in Hungary
Electric grids will go dark, bridges will crumble, solid ground will liquefy, and residents will find themselves in deep doo-doo — literally. The goal is to convince Northwesterners to include two buckets — one for No. And there will be a lot of poop bags.
Carpet Bombing is a retro-style, 2D aircraft arcade game. Fly a jet fighter and engage Release Date: Jan 9, Visit the website · View.
Carpet bombing Carpet-Bomb the most vocal soviet-made of a guest to indicate bomb a found of dresden has near time and brush lots of a dating. Dating, i should carpet bombing raid on other weapon was bombed in carpet ocean with email after obama. Air power had carpet carpet it is. C-Print mounted on the tactic in the early hours of the most vocal advocate of the u.
Essence may be a pun war. Just sent like 5, conflict in order, but it’s friday night. I only have tiny hairs that time and. Napalm is, ; release date: edl. In strikes believed to be frequented by the bomb when the two near soviet-made in dating.
Bombing of Tokyo
On the night of March 9, , U. Almost 16 square miles in and around the Japanese capital were incinerated, and between 80, and , Japanese civilians were killed in the worst single firestorm in recorded history. They were planning a low-level bombing attack on Tokyo that would begin that evening, but with a twist: Their planes would be stripped of all guns except for the tail turret.
Carpet bombing refers to an ad campaign that aims to reach as many They all had Facebook & Instagram pages, up to date websites and.
Before June , Allied military strategy had been focused on the Mediterranean. Fighter-bombers proved to be the most effective in this vital ground support role, able to respond quickly and decisively against hidden and fleeting targets when called in by forward controllers. Light and medium bombers also proved their worth striking at enemy troop positions and communications behind the lines. This formation would support the Allied armies invading Europe, and later deploy to the continent and keep pace with the advance.
It was surmised that later on, with the troops ashore, the bombers could be called upon by army commanders for use against battlefield objectives. This had been his mantra since taking command in February The Americans, already committed to precision daylight attacks against key German industries like U-boats, ball-bearings and oil, were also hostile to a diversion of effort, although in their case the Luftwaffe was already a key objective.
Destruction of the Luftwaffe fighter force and its manufacturing base was the most important element. Bombing attacks would be too costly, and D-Day itself would fail, unless Allied air superiority was achieved. Unescorted raids in saw hundreds of bombers shot down, but by the beginning of the Americans had been reinforced, and were now protected by long-range P fighters.
The tide was about to turn in their favour. This was a series of systematic attacks on aircraft assembly plants. The factories proved more resilient than expected and production was only partially affected, but results in the air were better. The Luftwaffe, already pulled back from France and other fronts to defend Reich airspace, was now being decimated by free-ranging US fighters.
Does Carpet Bombing Work?
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The US air force has released a video showing fighter jets carpet-bombing an island it said was “infested” with Isis fighters. The footage shows.
Carpet bombing , also known as saturation bombing , is a large area bombardment done in a progressive manner to inflict damage in every part of a selected area of land. Carpet bombing is usually achieved by dropping many unguided bombs. Carpet bombing of cities, towns, villages, or other areas containing a concentration of civilians is considered a war crime  as of Article 51 of the Protocol I of the Geneva Conventions. The term obliteration bombing is sometimes used to describe especially intensified bombing with the intention of destroying a city or a large part of the city.
The term area bombing refers to indiscriminate bombing of an area and also encompasses cases of carpet bombing, including obliteration bombing. It was used in that sense especially during World War II. One of the first cases of carpet bombing was by the Nazi German Condor Legion during the Spanish Civil War against Republican infantry during the Battle of El Mazuco ,   fought between 6 and 22 September , where the targeted troops were dispersed on rocky slopes and the Condor Legion learned that carpet bombing was not very effective in such terrain.
However, from 16 through 18 March , the Bombing of Barcelona took place successfully, when a series of Fascist Italian and Nazi German airstrikes killed up to 1, people and left at least 2, wounded. They were carefully designed and recorded, gathering crucial information in preparation for the European War that was around the corner. It is considered the first carpet bombing from air in history,  and a sad precedent of several such bombings in World War II carried out by both parties.
In the European Theatre , the first city to suffer heavily from aerial bombardment was Warsaw , on 25 September The objective was to support the German assault on the city, break Dutch resistance, and force the Dutch to surrender. Despite a ceasefire, the bombing destroyed almost the entire historic city centre, killing nearly nine hundred civilians and leaving 30, people homeless.